Cervical cancer

Questions and Answers

Question:

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Does the RAIDs project include all types of cervical cancer or only squamous cell cervical cancer? Thank you
Answer:

Answer:

Thank you for your interest in RAIDs project.

All patients with cervical cancer (squamous cell cancer, adenocarcinoma, adeno-squamous) which has not been previously treated and can undergo the standart treatment in participating centers are eligible to participate in the BioRAIDs clinical study, which is a part od RAIDs project and serves to collect the biological material for analysis.

This dropbox however is not restricted to the patients participating in the RAIDs project. The main objective of this dropbox is to understand the concerns and needs of patients with cervical cancer and therefore its open to all patients.

Please don\'t hesitate to ask further questions. Thank you.

Question:

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Hello, I would like to know which treatment can be proposed for the patient diagnosed with IIB stage of cervical cancer? Thank you
Answer:

Answer:

Thank you for your question.

The recommended treatment for stage IIB is upfront radiation therapy with chemotherapy (concurrent chemoradiation).

For diagnostic purposes and in order to verify whether the cancer has spread to the retroperitoneal lymph nodes, an optional surgery -retroperitoneal staging by laparoscopy- might be proposed. 

Radiotherapy: Radiation therapy will be administered in 5 fractions. The size of the irradiated area varies depending on the lymph node involvement. The most recent recommendations for magnetic resonance imaging (MRI) provides better images of the cervix, in addition it is extremely helpful to locate the cervical tumor precisely, to guide radiation therapy, as well as for monitoring of treatment response. Following the 6-8 weeks primary combined therapy additional irradiation might be proposed by your radiotherapist depending on your cancer and response. A final external boost of radiotherapy or the insertion of small radiotherapy capsules directly into the tumor area (brachytherapy) might be recommended by your physician. Again this is ideally image guided.

Chemotherapy consists in 5 to 6 weekly cycles of cisplatinum. In some cases (adenocarcinoma, incomplete local response) hysterectomy must be performed.

Surgery at the end of combined radio chemotherapy may be indicated in some cases.

In centers where a PET scanner is available, this imaging technique has been proofed useful for surveillance after treatment.

Please do not hesitate to contact us if you have any further questions or concerns.

Question:

What is the duration of treatment of cervical cancer stage III ?

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In cit timp se trateaza cancerul la a treia stadie?
Answer:

The duration of treatment for stage IIB-IIIB cervical cancer is at least 6 weeks (combined treatment by irradiation and chemotherapy) and ideally the treatment should not take more than 52 days.

 

An additional irradiation - by insertion of small radiotherapy rods directly  into the tumor area brachytherapy - might be suggested by your radiotherapist, depending on the extent of your cancer and  in particular  on initial treatment response. This can be done during the initial 6 weeks or later. Occasionally enlarged lymph nodes may need a “boost” of radiotherapy at the end.

 

In some cases surgery may be indicated and is carried out a few weeks after the end of the combined radio chemotherapy.

 

This duration may vary as a function of tolerance to treatment. Insufficient tolerance (such as diarrhea) may need treatment interruption for a variable amount of time.

 


Answer:

Durata tratamentului pentru stadiile IIB- IIIB de cancer a colului uterin este cel putin de 6 saptamini (tratament combinat prin radiatie si chimioterapie) si in caz ideal tratamentul nu dureaza mai mult de 52 de zile.


O iradiere in plus prin introducerea ‘’radiotherapy rods’’ direct in regiunea tumorei “brachyterapie”- va poate fi propus de medical radioterapeut, in functie de extindere a cancerului si in special in dependenta de rezultatul primului tratament. Aceasta poate fi realizat in cele 6 saptamini de tratament sau mai tirziu. Ocazional nodurile limfatice inlargite au nevoie de « boost » de raditerapie la sfirsit.


In unele cazuri o interventie chirurgicala poate fi prescrisa, si este realizata citeva saptamini mai tirziu dupa tratamentul combinat radio-chimioterapie.


Aceasta durata depinde deasemeni de toleranta la tratament . Toleranta insuficienta (diaree de exemplu) poate fi un motiv de intrerupere a tratamentului pe o durata variabila.

Question:
Cervical cancer
My wife has had a radical hysterectomy with lymph node dissection followed by radiotherapy (32 sessions) and 4 sessions of brachytherapy. Three months later she has a recurrent tumor of 2 cm which is blocking the urethra and therefore perturbing her renal function.
MRI analysis revealed one lymph node potentially involved with tumor. Biopsy of this lymph node was performed today. That is all we know.
Her physician gave her a 3 - 5 years life expectancy.  
We are lost and need your help and advice.  

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cancer du col de l\'utérus

ma femme a subit :opération l’hystérectomie totale élargie puis radiothérapie 32 séance et 4 séance de braco thérapie puis 3 mois après récidive une tumeur de 2 cm qui appuis sur l\'urètre et dons disfonctionnement du rein. Elle passe une IRM pour vérifier le restant du corps et la il reste un ganglions qui apparait en sur brillance donc biopsie faite ce jour Donc on ne sait pas tout de plus le docteur lui a donner une espérance de vie de 3 a 5 on est perdu besoin d\'aide et de conseil

Answer:

Dear Sir
We fully understand your worries and concerns.
Based on their precise knowledge of the medical history and clinical state, the multidisciplinary team involved in the care of your spouse gave you an answer to your questions, which appears adequate to us and reflects proper treatment in regards to the present available therapies in cervical cancer.
Unfortunately we do not have innovative treatment options to propose at the present time, except for a new line of chemotherapy, the long term efficacy of which is uncertain, but it can provide symptom relief.
It might also be helpful to you and your family to meet with a team of psychologists who are normally present in the majority of hospitals and who can provide advice.
We are trying to work out new treatment options in clinical trials. As these clinical trials become available the information will be posted on the RAIDs site.

Answer:

Cher Monsieur,
Nous comprenons tout à fait votre inquiétude. Néanmoins, l\'équipe pluridisciplinaire qui prend en charge votre épouse a donné un avis adapté à la connaissance de son dossier médical et de son état. Nous n\'avons malheureusement pas au jour d\'aujourd\'hui d\'autre option à vous proposer si ce n\'est une nouvelle ligne de chimiothérapie dont l\'efficacité sera probablement modeste. Il nous semble également indispensable que votre épouse et votre famille puissent être rencontrées par une équipe d\'aide psychologique comme il en existe dans la plupart des hôpitaux.
Croyez en l\'expression de nos sentiments dévoués.

Question:
I have cervical carcinoma stage 1. Can I receive a Gardasil vaccination?
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I have cervical carcinoma stage 1. Can I receive a Gardasil vaccination?
Answer:
Human papillomavirus (HPV virus) is commonly transmitted during sexual activity. Gardasil is a vaccine, which targets the outer membrane of four strains of human papillomavirus (HPV) - HPV-6, 11, 16, and 18. HPV-16 and HPV-18 account for about 70% of all cervical cancers. HPV-6 and HPV-11 cause about 90% of genital warts. HPV is also linked to anal cancer.
Studies have shown that Gardasil is close to 100% effective in the prevention of cervical pre-cancerous lesions caused by HPV-16 and HPV-18 in young adults not previously sexually active with no prior exposure to HPV.
Therefore in your case a vaccination unfortunately will not be useful because Gardasil generates a preventive immune response against the outer membrane of the virus.
There are therapeutic vaccines in clinical trials which are directed against the inner core of the virus. You can follow information on this on our website.
Answer:

Human papillomavirus (HPV virus) is commonly transmitted during sexual activity. Gardasil is a vaccine, which targets the outer membrane of four strains of human papillomavirus (HPV) - HPV-6, 11, 16, and 18. HPV-16 and HPV-18 account for about 70% of all cervical cancers. HPV-6 and HPV-11 cause about 90% of genital warts. HPV is also linked to anal cancer.
Studies have shown that Gardasil is close to 100% effective in the prevention of cervical pre-cancerous lesions caused by HPV-16 and HPV-18 in young adults not previously sexually active with no prior exposure to HPV.
Therefore in your case a vaccination unfortunately will not be useful because Gardasil generates a preventive immune response against the outer membrane of the virus.
There are therapeutic vaccines in clinical trials which are directed against the inner core of the virus. You can follow information on this on our website.

Question:
Hello! I have cervical cancer. Six weeks ago I did not know that I\'m sick and had been intimate with my husband. Please tell me if my husband is at risk? Thanks in advance!

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здравствуйте! у меня рак шейки матки. полтара месяца назад я не знала что больна и вступала с мужем в интимную связь. скажите пожалуйста, муж не является в зоне риска заболивания раком? заранее спасибо!
Answer:
Penile cancer is very rare and your husband is not at risk. He almost certainly will have had a passing HPV infection. HPV causes cancer only  in a fraction of the population whom it infects, mostly women, who are more exposed than men to a prolonged or repeatedinfection. The virus replicates in cells which proliferate and which are located in a specific area of the uterine cervix.
Answer:
Вашему мужу не угрожает опасность так как рак полового члена большая редкость. С большой вероятностью у него была временная (лёгкая) форма инфекции ВПЧ (вирус папилломы человека). ВПЧ вызывает рак только у доли населения являющейся вирусоносителем. В основном у женщин, которые более чем мужчины подвержены длительному или повторному заражению. Вирус распространяется в клетках, которые размножаются и которые расположены в определенной области шейки матки.
Question:

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How long treated cancer of the cervix?
Answer:

Answer:

The duration of treatment for stage IIB-IIIB cervical cancer is at least 6 weeks (combined treatment by irradiation and chemotherapy) and ideally the treatment should not take more than 52 days.


An additional irradiation - by insertion of small radiotherapy rods directly into the tumor area \\brachytherapy\\ - might be suggested by your radiotherapist, depending on the extent of your cancer and in particular on initial treatment response. This can be done during the initial 6 weeks or later. Occasionally enlarged lymph nodes may need a “boost” of radiotherapy at the end.


In some cases surgery may be indicated and is carried out a few weeks after the end of the combined radio chemotherapy.
This duration may vary as a function of tolerance to treatment. Insufficient tolerance (such as diarrhea) may need treatment interruption for a variable amount of time.

Question:
Hello! There are two types of cancer: squamous and adenocarcinoma. What are they?
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Здравствуйте! Существуют два вида рака: плоскоклеточный и аденокарцинома. Что это такое?
Answer:
Cervical cancer has most often (>90%) a squamous-type (cobblestone-like) appearance under the microscope. Much less frequent (5%) and slightly more difficult to treat is the glandular type. It has been suggested that this glandular type is associated with specific molecular alterations, different ones as compared to the squamous type. Occasionally both types of microscopic appearance can coexist in a tumor which is than called adeno-squamous.
Answer:
самый широко распространенный (> 90%) рак шейки матки это плоскоклеточный  вид (под микроскопом  подобен брусчатке) из клеток плоского эпителия. Значительно реже (5%) и немного более трудно поддается лечению это железистый тип. Существует предположение, что этот железистый тип связан с конкретными молекулярными изменениями, отличающимися от плоскоклеточного типа. Иногда оба типа микроскопической внешности могут сосуществовать в опухоли, которая тогда называется адено-плоскоклеточный.
Question:
I am a 53 year old senior secretary at the National Electric Societyin Kinshasa. There is a plant I would like your Institute to consider since it arrests cervical cancer progression if applied directly to the cervix. I believe that with further research one might be able to use this plant as a medication.
My email adress : gsikuvira@yahoo.fr
Thank you
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Je suis une femme de 53 ans,secrétaire de Direction à la société nationale d\'électricité, j\'habite à Kinshasa, j\'ai une plante à proposer à l\'institut concernant le cancer du col de l\'utérus, la plante en question peut stopper la progression du cancer du col si elle est appliquée directement sur le col de l\'utérus comme suppositoire. Je crois qu\'avec des recherches plus approfondies, on peut arriver à faire un médicament à base de cette plante. Mes coordonnées : gsikuvira@yahoo.fr Merci
Answer:
Would it possible to let us know more about the plant with anticancer activity? While visiting the Botanical garden of Cape Town in South Africa recently I came across the Gloriosa Superba plant.
This plant is considered toxic because it contains a chemotherapy called COLCHICIN which has been widely used in medicine. All 10 cell lines derived from patient tumours  we tested were significantly affected by Colchicin.
Many medications can be extracted from plants. The difficulty for patient treatment we encounter is that plants do not contain a single active ingredient, but a variety of ingredients which may have very different effects. Furthermore, depending on the soil they are growing on, the exposure to more or less sunlight will all affect the concentration of active ingredients, rendering them difficult to use for a given expected effect. Therefore pharma industries extract and purify ingredients and quantify them properly or chemically synthesize the compound.
Having said that, there is an official herbal medicine society in South Africa and it would be interesting to learn more about this.
Dr Scholl
Answer:
Mes collègues du RAIDS consortium et moi-même sommes curieux d’en savoir davantage sur votre plante à activité anticancéreuse. Je reviens d’un voyage en Afrique du Sud ou j’ai pu admirer dans le jardin botanique de Cape Town la Gloriosa Superba.
Cette plante est considérée comme toxique puisqu’elle contient de la Colchicine, un médicament largement utilisé en médecine pour diverses applications anti inflammatoires et anti cancéreuses. Nos 10 lignées cellulaires (dérivées de cancers du col) ont été significativement affectées par la Colchicine.
Beaucoup de médicaments sont extraits de plantes. La difficulté qu’on rencontre en médecine est que ces plantes ne contiennent pas des substances isolées et pures. La variabilité des substances peut entraîner des effets différents. La qualité du sol ainsi que le taux d’exposition au soleil peuvent affecter la concentration des ingrédients actifs. Tout ceci rend leur utilisation hasardeuse. Pour cette raison les industries pharmaceutiques préfèrent extraire et purifier les ingrédients désirés afin de les quantifier, ou alors ils les synthétisent chimiquement.
Ayant dit cela, il existe en Afrique du Sud une société officielle qui s’occupe de la guérison par les plantes et il serait très intéressant d’en savoir davantage.
Dr Scholl
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