The Institut Curie (IC) is a comprehensive cancer centre and a private non-profit foundation for public service. IC includes the largest French basic science campus for cancer research as well as a translational science platform, headed by Sergio Roman-Roman. It is a referral centre with a staff of > 3000 (>200 medical) involved in patient care, research and education and an annual load of > 12.000 new patients. It is certified by Inca (Institut national du cancer) to conduct early clinical trials (V Dieras), it has a technical platform controlling all aspects of clinical research (UGEC: P Tresca), clincical database and statistical controls (B Asselain). IC has a dedicated biobank and is a national repository for tumour tissues (>30.000) and derivatives (X Sastre).
Institut Curie (IC) is certified by Inca (Institut national du cancer) to conduct early clinical trials. 74 phase 1/ 2 clinical trials were conducted at Curie and 186 patients enrolled in 2010. A total of 19 trials were promoted by Curie in 2010.
Role within the project
The Translational laboratories platform (RPPA) and the bioinformatics unit together with SeqOmics (Hungary) will have a central role in biomarker detection. IC will also be instrumental in setting up the large cognitive trial (n=700) needed for the discovery of molecular alterations in cervical cancer, in the teaching for good clinical trial conduct to be implemented in all countries, and in the development of an eCRF in collaboration with the SME: Quanticsoft. Quality control aspects for standard therapy and for clinical monitoring will be set up by KEM (AGO) with the help of NKI, Curie and IGR and verified by senior clinical research assistants to be hired for this project. Basic science input from the largest French basic science campus for cancer research associated with the Curie clinical centre will be sought for stratification of patients during part II of RAIDs project into targeted therapy protocols (chemicals, vaccines, antiviral reagents). This is implemented through meetings by ETIC (Early Trials Institut Curie) a monthly exchange meeting for scientists and clinicians.
Description of key people involved in the project